Meet Dr. Charles L. Rosen

Dr. Charles Rosen’s neurosurgery expertise is focused on cranial base and neurovascular surgery, as well as complex intradural tumors of the third ventricle, posterior fossa, and spinal cord.

Dr. Rosen is currently at OSF HealthCare Illinois Neurological Institute where he practices in Bloomington, IL.

Dr. Rosen most recently served as Department Chair of Neurological Surgery at West Virginia University (WVU) School of Medicine from 2012 through 2017, following his 2011 appointment as Interim Department Chair.

He joined the faculty at WVU in 2001 and held various positions in the WVU Department of Neurosurgery, including vice chair, director of research and the neurosurgical research laboratories, and director of cranial base surgery.

He was professor of Neurosurgery and Program Director for Residency in Neurological Surgery in the WVU Department of Neurosurgery at WVU School of Medicine, among other academic and clinical roles.

While serving as the chair of WVU Department of Neurosurgery, Dr. Rosen managed development of the WVU Medicine Neurosurgery, Spine and Pain Center at United Hospital Center in Bridgeport, W.Va.

Dr. Rosen also served as the Medical Director for Neurosurgery at United Hospital Center, Ohio Valley Medical Center, and Wheeling Hospital.

While a neurosurgeon at West Virginia University, Dr. Rosen published on how the blood-brain barrier, inflammation, and repair are unique in the aged animal. Dr. Rosen is the author of more than 100 published articles and 11 book chapters.

From a research perspective, Dr. Rosen has maintained a funded laboratory studying the impact of aging on an animal model of cerebral ischemia. Dr. Rosen has also been studying the traumatic brain injury and, while in the West Virginia University Department of Neurosurgery, developed a model of blast injury.

Dr. Rosen led a team of physicians, computer scientists, engineers, and industry leaders on standardization of how DICOM (Digital Imaging and Communications in Medicine) imaging is distributed on computer media, as well as the development requirements for image viewers. This enables doctors all over the world to more easily collaborate on patient care–which allows , and to allow patients to readily bring MRI’s and CT scans from one physician to another.

He has received several honors, including election by his peers to the Society of Neurological Surgeons, The Society of University Neurosurgeons, and the Board of Directors of the American Association of Neurological Surgery. He also served as president of The Neurological Society of the Virginias. Dr. Rosen has had leadership roles in the Council of State Neurosurgical Societies, Congress of Neurosurgery, as well as West Virginia Neurosurgical Society.,

While practicing neurosurgery at WVU Department of Neurosurgery, Dr. Rosen was awarded the 2011 and 2013 Cornerstone Award from Jon Michael Moore Trauma Center at WVU. He was also the 2015 recipient of the Vice President of Health Science’s Award for Excellence in Clinical Service at WVU.

Dr. Rosen completed his undergraduate degree at Washington University in St. Louis, his master’s and doctorate degrees at the New York University Graduate School of Arts and Sciences, and his medical degree at the New York University School of Medicine. He completed neurosurgical residency training at George Washington University Medical Center in Washington, D.C. He is board certified in neurological surgery.

Dr. Rosen is married to wife, Lisa, mother of his two children–Rachel and Joshua. They enjoy both domestic and international travel. Dr. Rosen is an avid collector of classic sports cars and motorcycles.

Academic Appointments:

Professor, Department of Neurosurgery, West Virginia University School of Medicine,
Morgantown, WV (2012-2018).

Chair Department of Neurological Surgery, West Virginia University School of
Medicine, Morgantown, WV (2012-2017).

Interim Chair Department of Neurological Surgery, West Virginia University School of
Medicine, Morgantown, WV (2011-2012).

Vice Chair Department of Neurological Surgery, West Virginia University School of
Medicine, Morgantown, WV (2010-2011).

Program Director for Residency in Neurological Surgery, Department of Neurosurgery,
West Virginia University School of Medicine, Morgantown, WV (2008-2013).

Associate Professor, Department of Neurosurgery, West Virginia University School of
Medicine, Morgantown, WV (2006-2012).

Assistant Professor, Department of Neurobiology and Anatomy, West Virginia
University School of Medicine, Morgantown, WV (2002-2006).

Senator, West Virginia University, Morgantown, WV (12/2002 – 2006)

Assistant Professor, Director of Research and the Neurosurgical Research Laboratories,
Director of Cranial Base Surgery, Department of Neurosurgery, West Virginia
University School of Medicine, Morgantown, WV (2001-2006).

Neurosurgical Consultant. Southpaws Veterinary Hospital, Springfield, VA (1999-2001).

Academic Training:

Leksell Gamma Knife Training, Instructors: Bodo Lippitz, Bengt Karlson, Stockholm
Sweden, 9/2005.

Neurological Surgery Residency. Chairmen: Anthony J. Caputy, M. D. (March 1999- June 2001), Laligam N. Sekhar, M.D. (July 1995-February 1999), Department of Neurological Surgery, George Washington University Medical Center, Washington DC.

Pediatric Neurosurgery. Chairman: Philip H. Cogen, M.D., Ph.D. Department of
Neurological Surgery, Children’s National Medical Center and George Washington
University Medical Center, Washington DC. (January 2000 – June 2000).

Neuropathology. Chairman: Hernando Mena, M.D. Neuropathology Section, Armed
Forces Institute of Pathology, Washington DC. (January 1998-March 1998).

Microneurosurgery Dissection. Preceptor: Donald C. Wright, M.D. Department of
Neurological Surgery, George Washington University Medical Center, Washington DC .
(July 1997-October 1997).

Surgical Internship. Chairman: Joseph M. Giordano, M.D. Department of Surgery,
George Washington University Medical Center, Washington DC. (July 1994-June 1995).

M.D. New York University School of Medicine, New York, NY (May 1994).

Ph.D. “Neuronal Expression of Glycosylphosphatidylinositol (GPI) – Anchored
Proteins: Heterogeneity of Expression and Their Potential Role in Neuron-Glial
Interactions”, Thesis Advisor: James L. Salzer M.D., Ph.D. New York University
Graduate School of Arts and Sciences, New York, NY (January 1993).

M.S. “The Characterization, Cloning and Functional Studies of a
Glycosylphosphatidylinositol Linked Protein Present on Rat Sensory Neurons”,
Thesis Advisor: James L. Salzer M.D., Ph.D. New York University Graduate
School of Arts and Sciences, New York, NY (May 1991).

A.B. Washington University, St. Louis, MO (May 1987), XXXXXXXgrad mag.

Leadership Experience:

Developed a full-service spine center at United Hospital Center (UHC) in Bridgeport, WV. This involved recruiting all the physicians, advanced practice professionals, and staff, as well being a critical part of the design team for a new building designed for integrated care. Currently, after just a few years, UHC is composed of: 2 neurosurgeons, 2 pain management physicians, and 2 physiatrists, 7 advance practice professionals and 15 clinical/support staff. We have had a 30% increase in OR cases, 28% increase in pain procedures, and 48% increase in patient visits over a 3 year period. The success of UHC was so dramatic, that I was tasked with creating an integrated care site in Martinsburg , WV. I designed clinic space and recruited a physician and his group practice from Western Maryland to lead this development.

Prior to my becoming Chair, WVU had an outreach clinic/ care program in Wheeling, WV. During my tenure, we accomplished a 13% increase in OR cases without a decrease in cases at any other sites. In total, Since 2012 – the department under my leadership (all locations) has seen:

17% increase WRVUs
32% increase in OR cases
10% increase in patient visits

Other initiatives as Chair of the department included improving patient access. To this end we were able to substantially affect a number of important metrics:

6 week bump rate decreased from 12.35% in 2012 to 3.37%
Average new patient visit lag decreased from 43 days in 2012 to 17 days
Percent of new patients seen within 2 weeks increased from 19% in 2012 to 40% in 2017

Clinical Experience:

During the past ten years while having research, education and administrative responsibilities that have included Vice Chair, Program Director, Interim Chair, and Chair, I average more 11,500 wRVU’s. The majority of my clinical work has been focused on cranial base pathology, vascular surgery, as well as complex intradural tumors of the posterior fossa, third ventricle, and spinal cord.

Philanthropy:

Initiated the G. Robert Nugent Chair Fund, current donations in excess of $1,250,000.

Secured in excess of $250,000 in funds and equipment for the neurosurgery resident laboratory.

Medical License and Board Certification:

Diplomat of the American Board of Neurological Surgery # 24034, June 1, 2004 (MOC, up to date).

Medicine and Surgery, West Virginia, License #20488 (current).

Medicine and Surgery, District of Columbia, License #21644 (inactive).

Medicine and Surgery, Pennsylvania, License #01-155439 (inactive).

Committee Appointments:

OR Committee on Concurrent Surgery, West Virginia University School of Medicine,
Morgantown, WV (2017)

Search Committee for Director of Clinical Science in Stroke, (Dr. Todd Crocco, Chair of
Committee), West Virginia University School of Medicine, Morgantown, WV 2012.

Search Committee for Director of Basic and Translational Research in Stroke, (Dr. Glen
Dillon, Chair of Committee), West Virginia University School of Medicine,
Morgantown, WV 2012.

MD-PhD Adnission Committee, West Virginia University School of Medicine (2011-
2017).

Search Committee for Department of Translational Research, (Dr. Scot Remick, Chair of
Committee), West Virginia University School of Medicine, Morgantown, WV 2011.

Search Committee for the Chair of the Department of Opthalmology, (Dr. Steven
Wetmore, Chair of Committee), West Virginia University School of Medicine,
Morgantown, WV 2011.

Discovery and Innovation Committee, West Virginia University (2010).

MD-PhD Steering Committee, West Virginia University School of Medicine (2010).

MD-PhD Admissions Committee, West Virginia University School of Medicine (2009-
2017)

Search Committee, Stroke Director, West Virginia University School of Medicine (2009).

Committee member, MD-Ph.D. Program, West Virginia University School of Medicine
(August 2002-2017).

Committee member, Biomedical Research Development Grant Committee, West
Virginia University School of Medicine, Morgantown, WV (2002-2017).

Committee member for Anatomy and Neuroscience graduate exams, West Virginia
University School of Medicine, Morgantown, WV (2002-2017).

Senator, West Virginia University, Morgantown, WV (12/2002 – 2006)

Committee member, MD-Ph.D. Program, West Virginia University School of Medicine
(2001).

Administrative Appointments:

Medical Director, Neurosurgery, United Hospital Center, Bridgeport, WV (2012-2017).

Medical Director, Neurosurgery, Ohio Valley Medical Center, Wheeling, WV (2011-
2017).

Medical Director, Neurosurgery, Wheeling Hospital, Wheeling, WV (2011-2017).

Hospital Privileges:

Ruby Memorial Hospital Morgantown, West Virginia (July 2001-2018).

Wheeling Hospital, Wheeling, West Virginia (January 2003-2018).

Ohio Valley Medical Center, Wheeling, West Virginia (January 2003-2018).

United Hospital Center, Bridgeport, West Virginia (April 2012-2018)

Grants/Funding:

NIH 1R01NS099918-01A1, Therapeutic use of brostatin-1 to extend TPA time window following MCAO. PI: Jason Huber (Total Costs $1,630,657), Co-I ,2017-2022.

NIH 1R01NS073855-01A1, The role of CDK5 in stroke. PI: James Bibb (Total Costs $1,986,978.00), WVU PI/ Collaborator (subcontract $42,000/ annum) 2012-2017.

St. Jude Medical, Award RTU100061R, Partnership for Advancement in Neuromodulation (PAIN): A Prospective Clinical Outcomes Registry. PI: Chong Kim, Co-I Charles L. Rosen. 2013-2014: $12,300.

Medtronic Incorporated, Award RTU100113R. PROMISE. PI: Chong Kim Co-I Charles L. Rosen. 2013-2014: $13,999.

NIH 3R44NS060175-03S1, ” Combination Treatment of tPA and Apyrase for Stroke . CoInvestigator, $98,708 (total costs for WV Site), (9/11-8/12).

SyNAPSe, A randomized, double-blind, placebo-controlled phase 3 study to investigate the efficacy and safety of progesterone in patients with severe traumatic brain injury. Principal Investigator, WV site. Sponsor BHR Pharma, LLC, $1750/ enrolled patient with 26% indirects, (2009-2014).

HyperBranch Medical Technology, A pivotal clinical trial evaluating the safety and effectiveness of adheres dural sealant when used as a dural sealant in cranial procedures, Principal-Investigator, Estimate $2000/patient with 26% indirects.

NIOSH-927ZGHC, National Institute of Occupational Safety and Health. Shift work and stroke: Use of animal models to identify critical factors, Co-Principal Investigator, $337,256.00 Direct Costs (10/01/08-9/30/12)

NIH R01-NS061954-01, National Institute of Health, NINDS. Effect of age on BBB alterations following MCAO and reperfusion, Co-Investigator, $1,595,835.00, (1/08- 12/13).

Synthes, A prospective multicenter randomized controlled clinical study comparing syntheses durra replacement to other dura replacements in patients requiring dura repair following cranial surgery, Principal-Investigator, $140,353 (2006-2009).

A Prospective, Randomized, Controlled, Multicenter Pivotal Clinical Trial of the Artificial Cervical Disc – LP at Two Levels for Symptomatic Cervical Disc Disease, CoInvestigator,
$151,200 (2006-2008).

Randomized Evaluation of Convection Enhanced Delivery of IL13-PE38QQR Compared to GLIADEL Wafers with Survival Endpoint in Glioblastoma Multiforme at First Recurrence (PRECISE Trial). WVU Hospitals site for this International, Multisite, Phase III Clinical Trial, Co-Investigator, Direct cost estimate $112,000 / year, 2004 – 2006.

NOT-NS-03-011, National Institute of Health, NINDS, An Approach to Neutralizing a Neurotoxin out of Hospital, Co-Investigator, $29,500 (2003-2004)

American Heart Association. Student Fellowship for mentored student Dr. John Orphanos, Mentor $2000, Support July 2002-03.

West Virginia University, McGarvey Dean’s Fund, Principal-Investigator, $120,000, July 2002-2005.

Surgical Dynamics, Retrospective analysis of Ray cages in posterior lumbar intervertebral fusion, Principal Investigator, $12,000, Jan. 1999-Dec. 2000.

Examinations in Medicine:

ABNS, MOC, current.

ABNS Oral Exam, passed, May 2004.

ABNS Primary Exam, passed March 1999, ABNS# 27025.

USMLE Step 3, passed March 1995, NBME# 400751.

USMLE Step 2, passed March 1994, NBME# 400751.

NBME Part 1, passed June 1989, NBME# 400751.

Mentoring:

Graduate Students:

Richard Nolan, Graduate Student (PhD Candidate) 2017- 2018.

Brandon Lucke-Wold, Graduate Student (MD-PhD Candidate), 2012 – 2017.

Ryan Turner, Graduate Student (MD-PhD Candidate), 2009 – 2015.

Alisa Elliott, Graduate Student (PhD Candidate), 2010-2015

Zhenjun Tan, Postdoctoral Fellow, 2007-2015.

Mari Kusumi, Neurosurgical Research Fellow, 2010-2011.

Shusaku Noro, Neurosurgical Research Fellow, 2008-2010.

Rachel Leon, Graduate Student (MD-PhD Candidate), 2008 – 2011.

Alaina Smith, Graduate Student (PhD Candidate), 2010 – 2011.

C. Garret Cooper (MD-Ph.D. Candidate), member of Thesis Committee 2007-2010.

Kim Houser, Graduate (PhD Candidate) Student, 2006 – 2009.

Eric Scone, Graduate (PhD Candidate) Student, 2008-2009.

Michael Semenerio, Graduate (PhD Candidate) Student, 2008 – 2008.

Dr. Kazumi Homeric, Neurosurgical Research Fellow, 2004 –2006.

Vince DiNapoli, Graduate (MD-PhD Candidate) Student, 2003 –2006.

Dr. Tamaki Nagamine, Neurosurgical Research Fellow, 2002 – 2004.

Past Residents (Current Position):

Ali Sadr, MD (Faculty, SUNY Brooklyn)

Ken Price, MD (Faculty, UNC)

Ann Carr, MD (Private Practice, Fl)

Corbett Wilkinson, MD (Faculty, Univ of Colorado)

Vince Miele, MD (Faculty, UPMC)

David Pryputniewicz, MD (Private Practice, TN)

Todd Harshberger, MD (Private Practice, CA)

Brenton Coger, MD (Private Practice, MO)

John Orphanos, MD (Private Practice, WV)

James Mills, MD, (Private Practice, DE)

Jacinto Manon, MD (Private Practice, CO)

Cara Sedney, MD (Faculty, WVU)

Garret Jackson, MD (Faculty, IU)

Darnell Josiah, MD (Faculty, U Wisc)

Roy Hwang, MD (Fellowship, Albany Medical School)

Study Sections/Reviewer:

NIH G68 Study Section, Regional Stroke Coordinating Centers, Aug 2013.

Network of European Funding for Neuroscience Research (NEURON), “European research projects on cerebrovascular diseases”, 2011.

Rejuvenation Research, 2010- present.

Experimental Neurology, 2010- present

Journal of Neuroscience Methods, 2009-Present

Neurosurgery, 2009-present.

American Journal of Pathology (Senior Editor), 2009-present.

Journal of Neuro-Oncology, 2007-present.

Journal of Cerebral Blood Flow and Metabolism, 2007-present.

Neurol India, 2006-present.

Stroke, 2004-present.

Clinical Lymphoma, 2004 – present.

Professional Organizations and Societies:

Board of Directors, American Asscoiation of Neurological Surgery, 2015-2018.

Founding Member OneNeurosurgery, 2014-present.

Society of Neurological Surgeons, 2013 –present.

Society of University Neurosurgeons, 2012- present.

Member at Large, Board of Directors, NeurosurgeryPAC, (Appointed 2009, Reappointed 2011-17)

AMA Council on Ambulatory Safety National Agenda, Committee member 2011- 2015.

Medical Education Committee, American Association of Neurological Surgeons, 2012-15.

International Relations, American Association of Neurological Surgeons, 2011-2015.

Executive Committee, Member at Large, Congress of Neurological Surgeons, 2011-2012.

Chair of South East Quadrant, Council of State Neurosurgical Societies, 2011-2014.

President of the Neurosurgical Society of the Virginia’s, Term: January 2010-January 2012.

Chair, IHE (Integrating the Healthcare Enterprise) committee on DICOM Imaging and BIR (Basic Image Reviewer) 2008-2010.

North American Skull Base Society, Publication Committee, 2008 to 2013.

North American Skull Base Society, Research Committee, 2008 to 2011.

Neurosurgical Education Summit, CSNS representative, 2007-2008.

American Medical Association, Chair of Imaging and Patient Safety Committee, 2007-2011.

European Skull Base Society, advisory board 2006- present.

North American Skull Base Society, advisory board, 2006 to present.

Committee Member for the Council of State Neurosurgical Societies, Chair of CNS Caucus, and Vice Chair of Medical Practice Committee, 2005-2011.

Committee Member for the Congress of Neurological Surgery Education Committee, 2005-2016.

Fellow American College of Surgeons, 2005 to 2016.

West Virginia Society of Neurological Surgery 2001- 2018.

Monongalia County Medical Society, 2001 – 2015.

West Virginia State Medical Association, 2001 – 2015.

Neurosurgical Society of the Virginias, 2001 – 2018.

Oncology Section, Congress of Neurological Surgeons, 1998-2015.

American Association of Neurological Surgeons, 1996 to present.

Congress of Neurological Surgeons, 1995 to 2015.

The Society for Neuroscience, 1986 to 1994.

The New York Friends of Myelin, Officer, 1990 to 1994.

Officer of the New York City M.D./Ph.D. Student Forum, 1989 to 1994.

Patents:

Dry Eye Animal Model, provisional application numbered 61/403,977 filed on 9/24/2010.

Consulting/ Disclosures:

Twenty/20, consultant.

BrainLab, Munich Germany – consulting, teaching honorarium.

Synthes, Davos Switzerland- consulting, grant support.

Medtronic, Memphis, TN – teaching honorarium.

Hyperbranch Technologies – Grant Support.

BHR Pharma, LLC – Grant Support

Honors and Awards:

1987-1994 National Institute of Health Medical Scientist Trainee Award.

1983-1987 Dean’s List at Washington University.

1987 A.B., Washington University, awarded Magna Cum Laude.

1987 Marion Smith Spector Prize in the Biological Sciences, Washington
University. Advisor: Richard P. Bunge, M.D.

1993 Alpha Omega Alpha, Delta Chapter of New York, at New York University School of Medicine.

1993 Merck Scholar, The Merck Company Foundation.

2000 The Hugo V. Rizzoli Award for excellence in neurosurgical residency
training, George Washington University and Washington Hospital Center.

2004 Honored Visiting Professor, George Washington University, Washington DC.

2005 Dean’s Excellence Awards in Clinical Service, Stroke Program Development.

2007 Honored Visiting Professor, University of Washington, Seattle, WA.

2008 Honored Visiting Professor, University of Texas Southwestern, Dallas, TX.

2010 Guest Board Examiner for American Board of Neurological Surgery, Houston, TX

2010 Honored Visiting Professor, University of Mississippi, Jackson, MS.

2010 Elected Corresponding Member of the German Skull Base Society, Erfurt Germany.

2011 Cornerstone Award, Jon Michael Moore Trauma Center, West Virginia University, Morgantown, WV.

2013 Cornerstone Award, Jon Michael Moore Trauma Center, West Virginia University, Morgantown, WV.

2015 Vice President of Health Science’s Award for Excellence in Clinical Service, West Virginia University, Morgantown, WV.

Employment History:

1983-1986 Laboratory Technician for John P. Merlie, Ph.D. Department of Pharmacology, Washington University School of Medicine.

1983-1987 Assistant Field Director of Washington University Emergency Support Team.

1984-1985 Laboratory Technician for Marilyn Krukowski, Ph.D., Department of Biology, Washington University.

1985-1987 Teaching Assistant at Washington University for classes in:
Vertebrate Structure, Course Director Marilyn Krukowski, Ph.D.
Vertebrate Embryology, Course Director Thomas Kirk, Ph.D. Human
Biology, Course Director Johns Hopkins III, Ph.D.

1990 Teaching Assistant at New York University School of Medicine for Cell Biology, Course Director Gert Kreibich, Ph.D.

Invited Lectures and Courses:

June 1992 DAP, its role in neuron glial interactions. New York Friends of Myelin, Hunter College, New York, NY.

Aug. 1992 5’NT and neuronal ensheathment fates. Oklahoma Medical Research Foundation, Oklahoma City, OK.

Feb. 1994 GPI-anchored proteins and neuronal diversity. Meeting on GPIAnchored Proteins, Angra dos Reis, Rio de Janeiro, Brazil.

Sept. 1997 Assistant Instructor at Course on Extreme Far Lateral Approach, Congress of Neurological Surgery, Boston, MA. Course Director:
Donald C. Wright, M.D.

Nov. 1999 Assistant Instructor at Course on Lateral Skull Base Approaches, Congress of Neurological Surgery, Boston, MA. Course Director:
Donald C. Wright, M.D.

Sept. 2001 Cranial base surgery: safe removal of inoperable tumors, West Virginia University Neurosciences Teaching Weekend, Morgantown, WV.

Oct. 2001 GPI-anchored proteins and neural diversity: A Possible Tool for Understanding Head Injury, Dept. of Anatomy and Neurosciences, Morgantown, WV.

Jan. 2002 New techniques in cervical spine instrumentation. Trauma
Surgery Grand Rounds, West Virginia School of Medicine, Morgantown, WV.

Feb. 2002 Surgical management of subaxial spine injuries, Neurotrauma and Sports Medicine Review, Orlando, FL.

April 2002 New techniques and approaches in cranial base surgery. Pediatric Grand Rounds, West Virginia School of Medicine, Morgantown, WV.

June 2002 New directions in research for the neurosurgery department. Second Annual G. Robert Nugent Lectureship, Morgantown, WV.

July 2002 Surgical resection and reconstruction for anterior spinal tumors:
Anatomy, surgical techniques and instrumentation. West Virginia University Spinal Dissection Course (Course Director), Morgantown, WV.

Sept. 2002 Image Guided Neurosurgery. Advances in Neurosciences: 2002 Annual Neuroscience Review. CAMC Health Education and Research Institute, Charleston, WV.

Oct. 2002 Image guided surgery for neuro-oncology. Surgery Updates 2002:
Surgical approaches to cancer patients. Department of Surgery, West Virginia School of Medicine, Morgantown, WV.

Nov. 2002 The transbasal approach to clival lesion. International Neurosurgery Education Foundation, Cranial base dissection course. West Palm Beach, FL.

Nov. 2002 Management of cervical spine injuries and degenerative spine disease. Surgical Ground Rounds, Sofamor-Danek Cervical Spine Review, Memphis, TN.

Jan. 2003 Changing indications for extracranial-intracranial bypass. Society of the Virginias, Hot Sulphur Springs, VA.

Feb. 2003 Neurosurgical management of head injuries in athletes. Neurotrauma and Sports Medicine Review, Orlando, FL.

Sept. 2003 The role of extracranial-intracranial bypass for ischemic disease. Emergency Medicine Grand Rounds, Morgantown, WV.

Oct. 2003 Bypass Surgery Controversies. 3rd annual temporal bone dissection course and International Symposium on clinical neurosciences and cerebrovascular skull base surgery (Course Director and lecturer), Morgantown, WV.

Nov. 2003 Modified transbasal approach to the anterior cranial base and clivus. International neurosurgery education foundation, Cranial base dissection course. West Palm Beach, FL.

Feb. 2004 Surgical indications for EC-IC bypass. Neurology Grand Rounds, Morgantown, WV.

Mar. 2004 Orbitozygomatic approaches to the cavernous sinus and parasellar region, anatomy of the orbit and orbital cranial approaches (Course Director and lecturer), Morgantown, WV.

April 2004 Spinal cord injury, pathophysiology and management issues, Combined Neurosurgery and Orthopaedic Surgery Grand Rounds, Morgantown, WV.

June 2004 The role of aging in stroke, Neurosurgery Grand Rounds, Morgantown, WV.

Sept. 2004 Subaxial spine Injuries. Combined Neurosurgery and Orthopaedic Surgery Grand Rounds, Morgantown, WV.

Sept. 2004 Advanced cranial reconstruction, Synthes Surgical Symposium, Philadelphia, PA.

Oct. 2004 Trials and tribulations of BrainLab navigation. Congress of Neurological Surgery, San Francisco, CA.

Dec. 2004 A new “old” approach to studying stroke. George Washington University Neurosurgery Grand Rounds, Washington DC.

Jan. 2005 The importance of age in an embolic model of stroke. Society of the Virginias, White Sulphur Springs, WV.

Mar. 2005 Course Director and lecturer. 4th annual temporal bone dissection course and International Symposium on clinical neurosciences, Morgantown, WV.

April 2005 Invited faculty and lecturer on cranial surgery, extracranialintracranial bypass, BrainLab Residents Academy, Munich, Germany.

May 2005 Management of complex aneurysms and vascular bypass, Charleston Area Medical Center Grand Rounds, Charleston, WV.

Oct. 2005 Transbasal Surgery, complication avoidance and patient selection, The 64th Annual Meeting of the Japan Neurosurgical Society, Yokohama, Japan.

Jan. 2006 Combined Anesthesia – Neurosurgery Grand Rounds. Chiari I malformation and basilar invagination, West Virginia University, Morgantown, WV.

Feb. 2006 Complication avoidance for anterior cranial base tumors, North American Skull Base Meeting, Phoenix, AZ.

April 2006 Invited faculty and course director, BrainLab Residents Academy. Lectured on anterior cranial base surgery, extracranialintracranial bypass, and development of strategic alliance, Munich Germany.

May 2006 Transbasal Surgery, Techniques and Complication Avoidance, Advanced SkullBase Microanatomy and Hands-On Dissection Workshop. West Palm Beach, FL.

June 2006 Oncology Grand Rounds. Surgical treatment of anterior cranial base tumors, West Virginia University, Morgantown, WV.

July 2006 Invited faculty and keynote lecturer, Montana Neurosurgery Symposium, Big Sky, Montana.

July 2006 Combined Anesthesia – Neurosurgery Grand Rounds. Vertebral Superior Cerebellar Bypass, a solution for a difficult problem, West Virginia University, Morgantown, WV.

Sept 2006 Invited Lecturer and Moderator West Virginia Neuroscience Retreat, Nemacolin Woodlands, PA.

Mar. 2007 A new approach to studying stroke, the role of the blood brain barrier. Southern Neurosurgical Society. Sea Island, GA.

Mar. 2007 A new “old” approach to studying stroke. Neurosurgery Grand Rounds. University of Washington School of Medicine, Seattle WA.

May 2007 The pendulum of endoscopic pituitary surgery. European Skull Base Society, Prague, Czech Republic.

Nov. 2007 Goodman oral board preparation neurosurgery review by case management, Houston, TX.

Jan. 2008 The role of the blood brain barrier in an aged model of ischemia. Society of the Virginias, White Sulphur Springs, WV.

April 2008 Update on neurosurgical education, Council State Neurosurgical Societies, Chicago, IL.

May 2008 Is aging important in cerebral ischemia? Noted Neuroscience Lecture Series at Alfried Krupp Wissenschaftskolleg, Greifswald, Germany.

June 2008 Changing indications of vascular bypass. Roma International Workshop on Cerebrovascular and Skull Base Surgery, Rome, Italy.

June 2008 Endonasal versus endoscopic pituitary surgery. Roma International Workshop on Cerebrovascular and Skull Base Surgery, Rome, Italy.

Sept. 2008 Instructor CNS Oral Boards Remediation Course. Orlando FL.

Sept. 2008 Council State Neurosurgical Societies, Medical Imaging, and the problems of current standards, and lack thereof. Orlando, FL.

Oct. 2008 The role of aging and the BBB in stroke, UTSW Grand Rounds, Dallas, TX.

Nov. 2008 Goodman oral board preparation neurosurgery review by case management, Houston, TX.

Nov. 2008 Emerging Technologies, Course Director and participant, Las Vegas, NV.

Jan. 2009 MR imaging update, or “How do I get the #^%# Disc to open?” Society of the Virginias, White Sulphur Springs, WV.

Mar. 2009 Director BrainLAB Chief Resident Academy, Munich, Germany.

April 2009 Techniques of Complication Avoidance and Reconstruction for Anterior Cranial Base Surgery, European Skull Base Society, Rotterdam Netherlands.

April 2009 My worst Surgical Complication and what I wish I did, didn’t do, and what I will do next time, European Skull Base Society, Rotterdam Netherlands.

June 2009 A new “old” method for studying stroke. Neurosurgical Society of America, Hot Springs, Va.

Oct. 2009 The importance of understanding aging in a cerebral model of ischemia, Invited Guest Lecturer, Japanese neurosurgical Society, Tokyo, Japan.

Oct. 2009 Course Director CNS Oral Boards Review, New Orleans LA.

Nov. 2009 Goodman oral board preparation neurosurgery review by case management, Houston, TX.

Dec. 2009 Working towards patient safety in digital imaging, concepts for a basic image viewer, RSNA, Chicago, Il.

May 2010 Solutions to problems with digital Imaging, CSNS Update, Philadelphia PA.

Aug. 2010 A new “old” method for studying stroke. Visiting Professor, University of Mississippi, Jackson, MS

Sept. 2010 Complication avoidance in anterior cranial base surgery, German Skull Base Meeting, Erfurt, Germany.

June 2011 The role of hormone replacement therapy in ischemic injury, Society of University Neurosurgeons, Istanbul, Turkey.

Aug. 2011 Complication avoidance in anterior cranial base surgery, ENT Grand Rounds, Morgantown, WV.

Oct. 2011 Cerebral Vascular Anatomy and Pathophysiology, Association of Neurosurgical Physician Assistants, Washington, DC.

Mar. 2012 Craniectomy for ischemia and trauma, when is enough, enough, Society of University Neurosurgeons, Atlanta , GA.

Mar. 2012 CDK5 activation and neuroprotection in an aged animal model of ischemia. Society of University Neurosurgeons, Atlanta , GA.

April. 2012 The activities of the Southeast quadrant of the CSNS. Council of State Neurosurgical Societies, Miami , FL.

Sep. 2012 CDK5 activation and neuroprotection in an aged animal model of ischemia and the opportunity for studying blast injury, Neurosurgery Grand Rounds, Morgantown, WV.

Mar 2013 A Career in Neurosurgery, West Virginia University Neuroscience Symposium, Morgantown, WV.

April 2013 Head Injury, WVU School of Medicine Neuroscience Course, Morgantown, WV.

April 2013 Malignant Gliomas, an update on standards of care, American Association of Neurological Surgery, New Orleans, LA.

April 2013 Activities and Accomplishments of the Southeast Quadrant, Update to the CSNS, New Orleans, LA.

June 2013 Modeling Clinically Relevant Blast Parameters based on Scaling Principles Produces Functional and Histological Deficits in Rats, Society of University Neurosurgeons, Marbella Spain.

June 2013 Resection of a dAVF with Stroke and Mortality as an Outcome, Clinical Complications in Cerebrovascular Disease, Jackson Hole, WY.

June 2013 Moderator for complications in management of aneurysms, Clinical Complications in Cerebrovascular Disease, Jackson Hole, WY.

Feb 2014 Advanced Neuroscience Lecture Series: Aging and ischemic injury: New Ways to Look at an Old Problem, Visiting Professor, Fairfax Inova Neurosciences, Fairfax, Va.

June 2014 Mea Culpa, Session organizer and Moderator, European Skull Base Society, Paris France.

July 2015 Altering ER Stress in a Model of Blast-Induced TBI Controls Cellular Fate and Ameliorates Neuropsychiatric Symptoms, Society of University Neurosurgeons, Shanghai, China.

Sep 2015 ER Stress modulation as a target for ameliorating effects of blast induced traumatic brain injury, American Academy of Neurosurgery, Heidelberg, Germany.

Nov 2015 2015 International State-of-the-Science Meeting on, “Does Repeated Blast-Related Trauma Contribute to the Development of Chronic Traumatic Encephalopathy (CTE)?”, U.S. Army Medical Research and Materiel Command, Fairfax Va.

Spring 2016 Lecturer in WVU School of Medicine Neuroscience course for First Year Medical Students.

Spring 2017 Lecturer in WVU School of Medicine Neuroscience course for First Year Medical Students.

July 2017 Invited presentation of role of Bryostatin in extending TPA time Window administration. Society of University Neurosurgeon, Cape Town, South Africa.

Nov 2017 Grand Rounds, University of Cincinnati, Department of Neurosurgery, Ischemia, Using an “Old” Model for New Insights, Cincinnati, OH.

Dec 2017 Grand Rounds, McMaster University, Division of Neurosurgery, Ischemia, Using an “Old” Model for New Insights. Hamilton, Ontario.

Publications

Papers:

Rosen CL, Bunge RP, Ard MD, Wood PM. Type 1 astrocytes inhibit myelination
by adult rat oligodendrocytes in vitro. J Neurosci. 1989; 9(10):3371-3379.
Rosenbluth J, Hasegawa M, Shirasaki N, Rosen CL, Liu Z. Myelin formation
following transplantation of normal fetal glia into myelin-deficient rat spinal
cord. J Neurocytol. 1990;19(5):718-730.
Rosen CL, Lisanti MP, Salzer JL. Expression of unique sets of GPI-linked
proteins by different primary neurons in vitro. J Cell Bio. 1992; 117(3):617-627.
Struyk AF, Canoll PD, Wolfgang MJ, Rosen CL, D’Eustachio P, Salzer JL.
Cloning of neurotrimin defines a new subfamily of differentially expressed
neural cell adhesion molecules. J Neurosci. 1995; 15(3):2141-2156.
Struyk AF, Rosen CL, Salzer JL. Role of GPI anchored proteins in neural cell
adhesion. Advances in Molecular & Cell Biology. 1996; 16:193-222.
Salzer JL, Lovejoy L, Linder MC, Rosen CL. Ran-2, a glial lineage marker, is a
GPI-anchored form of ceruloplasmin. J Neurosci Res. 1998; 54(2):147-157.
Levine ZT, Buchanan RI, Sekhar LN, Rosen CL, Wright DW. A proposed grading
system to predict full resection in cranial base meningiomas. Neurosurgery. 1999;
45(1):221-230.
Rosen CL, Sekhar LN, Duong DH. Use of intra-aortic balloon pump
counterpulsation for refractory symptomatic vasospasm. Acta Neurochir (Wein).
2000; 142(1):25-32.
Rosen CL, DePalma L, Morita A. Primary angiitis of the central nervous system
as a first presentation in Hodgkin’s disease: a case report and review of the
literature. Neurosurgery. 2000; 46(6):1504-1510.
Rosen CL, Ammerman J, Sekhar LN, Bank WO. Outcome analysis of
preoperative embolization in cranial base surgery. Acta Neurochir (Wien). 2002;
144(11):1157-1164.
Carr AM, Bailes JE, Helmkamp JC, Rosen CL, Miele VJ. Neurological injury and
death in all-terrain vehicle crashes in West Virginia: a 10-year retrospective
review. Neurosurgery. 2004; 54(4): 861-866.
Carpenter J, Rosen CL, Bailes JE, Galloud P. Sinus pericranii: clinical and
imaging findings in two cases of spontaneous partial thrombosis. AJNR Am J
Neuroradiol. 2004; 25(1):121-125.
Sivak-Callcott J, Carpenter JS, Rosen CL, Ellis B, Hix C. Gaze-evoked amaurosis
associated with an intracranial aneurysm. Arch Opthalmol. 2004; 122(9):1405-1406
Miele VJ, Rosen CL, Carpenter JP, Rai AT, Bailes JE. Vertebral artery to middle
cerebral artery bypass with coil embolization of giant internal carotid artery
aneurysm: technical case report. Neurosurgery. 2005; 56(5):1159-1160.
Rosen CL, DiNapoli VA, Nagamine T, Crocco T. Influence of age on stroke
outcome following transient focal ischemia. J Neurosurg. 2005; 103(4):687-694.
Rai AT, Rosen CL, Carpenter JS, Miele VJ. Epidural blood patch at C2: diagnosis
and treatment of spontaneous intracranial hypotension. AJNR Am J Neuroradiol.
2005; 26(10):2663-2666.
DiNapoli VA, Rosen CL, Nagamine T, Crocco T. Selective MCA occlusion: A
precise embolic stroke model. J Neurosci Methods. 2006; 154(1-2):233-238.
Hartel P, Rosen CL, Larzo C, Nestor S. Malignant optic nerve glioblastoma
multiforme: case report and literature review. W V Med J. 2006; 102:29-31.
Karlsson B, Lax I, Yamamoto M, Soderman M, Jokura H, Rosen C, Bailes, J.
Calculation of isoeffective doses and the alpha/beta value by comparing results
following radiosurgery and radiotherapy for arteriovenous malformations of the
brain. J Neurosurg. 2006; 105 Suppl: 183-9.
Karlsson B, Rosen C, Lippitz B, Söderman M. Asymptomatic Cavernous Sinus
Meningiomas—To Watch or To Treat? Skull Base-an Interdisciplinary Approach.
2007, 17.
Rosen C. Complication Avoidance in Anterior Cranial Base Surgery. Skull Basean
Interdisciplinary Approach. 2007,17.
Sivak-Callcott J, Rosen CL, Rassekh C, Van,Der Sloot P, Karlsson B.
Collaborative Approaches to Orbital-Cranial Disease: Ophthalmic Perspective.
Skull Base-an Interdisciplinary Approach. 2007, 17.
Vidor I, Sivak-Callcott J, Rosen CL, Rassekh C, Williams HJ, Ellis B. Chordoma
of the anterior cranial fossa and ethmoids with orbital involvement. Orbit. 2008;
27(6):444-450.
Rosen CL, Sedney C, Sivak J. Single-stage complex reconstruction for fibrous
dysplasia: a case report. Skull Base. 2008; 18(4):275-279.
Miele VJ, France JC, Rosen CL. Subaxial positional vertebral artery occlusion
corrected by decompression and fusion. Spine. 2008; 33(11):E366-370.
DiNapoli VA, Huber JA, Houser K, Li X, Rosen CL. Early disruptions of the
blood-brain barrier may contribute to exacerbated neuronal damage and
prolonged functional recovery following stroke in aged rats. Neurobiol Aging.
2008; 29(5):753-764.
Rosen CL, Orphanos J, Nugent RG, Marano G. The use of MR-myelography
combining flexion and extension imaging in the diagnosis of cervical
myelopathy: a case report. W V Med J. 2009; 105(1):10-14.
Tan Z, Li X, Kelly KA, Rosen CL, Huber JD. Plasminogen activator inhibitor type
1 derived peptide, EEIIMD, diminishes cortical infarct but fails to improve
neurological function in aged rats following middle cerebral artery occlusion.
Brain Res. 2009, 1281:84-90.
Kelly K, Li X, VanGilder R, Tan Z, Rosen CL, Huber J: NOX2 inhibition with
apocynin worsens stroke outcome in aged rats. Brain Research 2009; 1292:165-172.
Fancy T, Rosen C. Endoscopic Repair of Cerebrospinal Fluid Leaks: A Review of
Cases. Skull Base-an Interdisciplinary Approach; 2009(19).
Bulsara KR, Hoh B, Rosen CL, Tanikawa R, Carpenter J: Preliminary
Observation on Predicting the Need for Coil extraction During Microsurgery:
The Clip-Coil Ratio. Acta Neurochir 2010, 152:431-434.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&
dopt=Citation&list_uids=19921093.
DiNapoli VA, Benkovic SA, Li X, Kelly KA, Miller DB, Rosen CL, Huber JD,
O’Callaghan JP. Age exaggerates proinflammatory cytokine signaling and
truncates signal transducers and activators of transcription 3 signaling following
ischemic stroke in the rat. Neuroscience 2010; 170:633-644.
Marhold, F, Rosen, CL: A novel technique to improve vessel mismatch when
using saphenous vein bypass grafts for intracranial revascularization procedures.
J Neurosurg. 2010; 112:127-1231.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&
dopt=Citation&list_uids=19780645.
Popa-Wagner A, Pirici D, Petcu EB, Mogoanta L, Buga AM, Rosen CL, Leon R,
Huber J. Pathophysiology of the vascular wall and its relevance for
cerebrovascular disorders in aged rodents. Current Neurovascular Research 2010;
7(3):251-67.
Sivak-Callcott JA, Diaz SR, Ducatman AM, Rosen CL Nimbarie AD, Sedgeman
JA. A survey of occupational pain and injury in ophthalmic plastic surgeons.
Opthal Plast Reconstr Surg 2011; 27:28-32.
Rosen CL, Sedney CL, Tally PW, Carmel PW, Sokol PE. Electronic medical
imaging: Organized medicine’s approach to improving patient care. Congress
Quarterly 2011; 12(1): 23-24.
Turner, RC , Dodson SC, Rosen CL. Medical Management of Cerebellar Abscess:
A Case Report & Literature Review. West Virginia Medical Journal; March/April
2011.
Sedney CL, Rosen CL. Cervical Abnormalities Causing Vertebral Artery
Dissection in Children. Journal of Neurosurgery: Pediatrics March 2011; 272-275.
VanGilder RL, Rosen CL, Barr TL, Huber JD. Targeting the neurovascular unit
for treatment of neurological disorders. Pharmacology and Therapeutics 2010;
130:239-247.
Rosen CL, Steinberg GK DeMonte F, Delashaw, Jr JB, Lewis SB, Shaffrey ME,
Aziz K, Hantel J, Marciano FP. Results of the prospective, randomized,
multicenter clinical trial of a biosynthesized cellulose versus commercially
available grafts for repair of dural defects. Neurosurgery 2011; 69:1093-1104.
VanGilder RL, Huber JD, Rosen CL, Barr TL. The Transcriptome of Cerebral
Ischemia, Brain Research Bulletin 2012; 88(4):313-9.
Leon RL, Huber JD, Rosen CL. Potential age-dependent effects of estrogen on
neural injury. Am J Pathol 2012; 178:2450-2460.
Leon RL, Xinlan X, Huber JD, Rosen CL. Worsened outcome from middle
cerebral artery occlusion in aged rats receiving 17β-estradiol. Endocrinology
2012; 153(7):3386-93.
Kusumi M, Fukushima T, Aliabadi H, Mehta AI, Noro S, Rosen CL. MicroplateBridge
Technique for Water tight Dural Closures in the Combined Petrosal
Approach. Neurosurgery 2012; 70(2 Supple Operative):264-9.
Sedney C, Rosen CL. Increased Quality and Standardization in Electronic
Medical Imaging to Improve Workflow. (currently in epress, AANS
Neurosurgeon 2012).
Wagner AP, Buga AM, Turner RC, Rosen CL, Toescu E. Cerebrovascular
disorders: role of aging, editorial. Journal of Aging Research 2012; 128146.
Turner RC, Lucke-Wold BP, Lucke-Wold N, Elliott AS, Rosen CL, Huber JD.
Neuroprotection for Ischemic Stroke: Moving Past Shortcomings and Identifying
Promising Directions. January 2013. International Journal of Molecular Sciences
14(1):1890-1917.
Turner RC, Seminerio MJ, Naser ZJ, Ford NJ, Neal SJ, Matsumoto RR, Rosen CL,
Huber JD. Effects of aging on behavioral assessment performance: implications
for clinically relevant models of neurologic disease. September 2012. Journal of
Neurosurgery 117:629-637.
Turner RC, Naser ZJ, Bailes JE, Smith DW, Fisher JA, Rosen CL. Effect of Slosh
Mitigation on Histologic Markers of Traumatic Brain Injury. December 2012.
Journal of Neurosurgery 117:1110-1118.
Turner RC, Dodson SC, Rosen CL, Huber JD. The science of cerebral ischemia
and the quest for neuroprotection: navigating past failure to future success. A
review. May 2013. Journal of Neurosurgery 118(5):1072-1085.
Lucke-Wold BP, Turner RC, Lucke-Wold AN, Rosen CL, Huber JD. Age and the
Metabolic Syndrome as Risk Factors for Ischemic Stroke: Improving Preclinical
Models of Ischemic Stroke. Yale Journal of Biology and Medicine. 85(4):523-39.
Turner RC, Naser ZJ, Logsdon AF, DiPasquale KH, Jackson GJ, Robson MJ,
Gettens RT, Matsumoto RR, Huber JD, Rosen CL. Modeling clinically relevant
blast parameters based on scaling principles produces functional & histological
deficits in rats. Exp Neurol (2013) 248:520-529.
Turner RC, Rosen CL. Comment on Zinkel JL – Rat Forebrain Perfusion In Vivo
by One Artery Like the Isolated Kidney Model: A Robust Recovery Model
Permitting Ischemia Without Anesthesia to Compare Multiple Brain Injury
States. April 2013 Neurosurgery 72:662-667.
Turner, RC, Lucke-Wold, B, Lucke-Wold, N, Elliott, AS, Logsdon, AF, Rosen, CL,
Huber, JD. Neuroprotection for Ischemic Stroke: Moving Past Shortcomings and
Identifying Promising Directions. Int. J. Mol. Sci. (2013) 14:1890-1917.
VanGilder RL, Davidov DM, Steinhart KR, Huber JD, Turner RC, Wilson KS,
Haney E, Davis SM, Chantler PD, Theekie LA, Rosen CL, Crocco TJ, Gutmann L,
Barr TL: Systematic review of Hs-CRP as a mediator of long-term functional
outcome for ischemic stroke. Journal of Clinical Neuroscience. . Epub ahead of
print. DOI: 10.1016/j.jocn.2013.06.015.
Fargen KM, Rosen CL. Are duty hour regulations promoting a culture of
dishonesty among resident physicians? Journal of Graduate Medical Education:
December (2013) 5(4):553-555.
Tan Z, Turner RC, Leon RL, Li X, Hongpaisan J, Zheng W, Logsdon AF, Naser
ZJ, Alkon DL, Rosen CL, Huber JD. Bryostatin Improves Survival and Reduces
Ischemic Brain Injury in Aged Rats after Acute Ischemic Stroke. Stroke (2013).
44(12):3490-3497
Jacobson J, Rosen CL, Rosseau G. Tribute to Norman Horwitz. World
Neurosurgery (2013) 79(5-6):610. DOI: 10.1016/j.wneu.2013.02.035.
Turner RC, Naser ZJ, Logsdon AF, DiPasquale KH, Jackson GJ, Robson MJ,
Gettens RTT, Matsumoto RR, Huber JD, Rosen CL. Modeling Clinically
Relevant Blast Parameters based on Scaling Principles Produces Functional and
Histological Deficits in Rats. October 2013. Experimental Neurology 248:520-
529.
Turner R.C., VanGilder R.L., Naser Z.J., Lucke-Wold B.P., Bailes J.E., Matsumoto
R.R., Huber J.D., Rosen C.L. (2014) Elucidating the Severity of Preclinical
Traumatic Brain Injury Models: A Role for Functional Assessment?
Neurosurgery. Epub ahead of print. PMID: 24448183.
Lucke-Wold B.P., Turner R.C., Logsdon A.F., Bailes J.E., Huber J.D., Rosen CL.
(2014) Linking Traumatic Brain Injury to Chronic Traumatic Encephalopathy:
Identification of Potential Mechanisms Leading to Neurofibrillary Tangle
Development. Journal of Neurotrauma. Epub ahed of print. PMID: 24499307.
Lucke-Wold B.P., Turner R.C., Logsdon A.F., Nguyen L., DiPasquale K., Huber
J.D., Rosen C.L. (2014) Metabolic Syndrome and its Profound Effect on the
Development of Ischemic Stroke. American Medical Student Research Journal.
Tan Z, Li, X, Turner RC, Logsdon AF, DiPasquale KH, Lucke-Wold BP, Chen R,
Huber JD, Rosen CL. Combination treatment of r-tPA and apyrase reduces
mortality rate and hemorrhagic transformation 6h after ischemic stroke in aged
female rats. Euro J Pharm (2014) 738: 368-373. (10.1016/j.ejphar.2014.05.052)
Meyer DA, Torres-Altoro MI, Tan Z, Tozzi A, DiFilippo M, DiNapoli V, Plattner
F, Kansy JW, Benkovic S, Huber J, Miller D, Greengard P, Calabresi P, Rosen CL,
Bibb JA: Ischemic Stroke Injury is Mediated by Aberrant Cdk5. J Neurosci (2014)
34(24): 8259-8267.
VanGilder RL, Steinhart K, Davidov DM, Huber JD, Turner RC, Wilson KS,
Haney E, Davis SM, Chantler PD, Theekie L, Rosen CL, Crocco T, Gutmann L,
Barr TL. Systematic Review of Hs-CRP and Long-term Ischemic Stroke
Prognosis. International Journal of Stroke. (Submitted September 2013).
Lucke-Wold BP, Logsdon AF, Smith KE, Turner RC, Alkon DL, Tan Z, Naser ZJ,
Knotts CM, Huber JD, Rosen CL. Bryostatin-1 Restores Blood Brain Barrier
Integrity following Blast Injury. Mol Neurobiol. 2014 Oct 10 [Epub ahead of
print].
Skolnick BE, Maas AI, Narayan RK, Hoop RG, Macallister T, Ward JD, Nelson
NR, Stocchetti N and Synapse Trial Investigators (lead investigator at West
Virginia University). A clinical trial of progesterone for severe traumatic brain
injury. N Engl J Med (2014) DOI: 10.1056/NEJMoa1411090.
Taylor S, Smith GH, Kaakaji W, McGregor J, Tomei K, Zacharia B, Dunn J, Rosen
CL. Primum nonnocere – surgical checklists. Congress Quartly. (2014) 15(4): 14-
15.
Bingham CM, Harris MA, Vidor IA, Rosen CL, Linberg JV, Marentette LJ, Elner
VM, Sivak-Callcott JA. Transcranial orbital decompression for progressive
compressive optic neuropathy after 3-wall decompression in severe graves’
orbitopathy. Ophthal Plast Reconstr Surg. 2014 May-Jun;30(3):215-8. doi:
10.1097/IOP.0000000000000052. PMID:24759290.
Logsdon AF, Turner RC, Lucke-Wold BP, Robson MJ, Naser ZJ, Smith KE,
Matsumoto RR, Huber JD, Rosen CL. Altering endoplasmic reticulum stress in a
model of blast-induced traumatic brain injury controls cellular fate and
ameliorates neuropsychiatric symptoms. Front Cell Neurosci. 2014 Dec 10;8:421.
doi: 10.3389/fncel.2014.00421. eCollection 2014. PMID:25540611.
Lucke-Wold BP, Logsdon AF, Turner RC, Rosen CL, Huber JD. Aging, the
metabolic syndrome, and ischemic stroke: redefining the approach for studying
the blood-brain barrier in a complex neurological disease. Adv Pharmacol.
2014;71:411-49. doi: 10.1016/bs.apha.2014.07.001. Epub 2014 Sep 12. Review.
PMID:25307225.
Logsdon AF, Lucke-Wold BP, Rosen CL, Huber JD 2014 Disparity among neural
injury models and the unfolded protein response. J Neurol Disord Stroke [Epub
ahead of print]
Lucke-Wold BP, Turner RC, Logsdon AF, Simpkins JW, Alkon DL, Smith KE,
Chen Y, Tan Z, Huber JD, Rosen CL. Common Mechanisms of Alzheimer’s
disease and Ischemic Stroke: the Role of Protein Kinase C in the Progression of
Age-related Neurodegeneration. Journal of Alzheimer’s Disease (2015) 43:711-
724.
Tan Z, Lucke-Wold BP, Logsdon AF, Turner RC, Tan C, Li X, Hongpaison J,
Alkon DL, Simpkins JW, Rosen CL, Huber JD. Bryostatin extends tPA time
window to 6h following middle cerebral artery occlusion in aged female rats.
Eur J Pharmacol. 2015 Jul 17;764:404-412. doi: 10.1016/j.ejphar.2015.07.035. [Epub
ahead of print] PMID: 26189021.
Logsdon AF, Lucke-Wold BP, Turner RC, Huber JD, Rosen CL, Simpkins JW.
Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury.
Compr Physiol. 2015 Jul 1;5(3):1147-60. doi: 10.1002/cphy.c140057.
PMID:26140712
Jackson GJ, Sedney CL, Fancy T, Rosen CL. Intraoperative neuronavigation for
transoral surgical approach: use of frameless stereotaxy with 3D rotational C-arm
for image acquisition. W V Med J. 2015 May-Jun;111(3):30-2, 34. PMID:26050295
Lucke-Wold BP, Smith KE, Nguyen L, Turner RC, Logsdon AF, Jackson GJ,
Huber JD, Rosen CL, Miller DB. Sleep disruption and the sequelae associated
with traumatic brain injury. Neurosci Biobehav Rev. 2015 Aug;55:68-77. doi:
10.1016/j.neubiorev.2015.04.010. Epub 2015 May 6. Review. PMID:25956251
Turner RC, Lucke-Wold BP, Logsdon AF, Robson MJ, Lee JM, Bailes JE,
Dashnaw ML, Huber JD, Petraglia AL, Rosen CL. Modeling Chronic Traumatic
Encephalopathy: The Way Forward for Future Discovery. Front Neurol. 2015 Oct
26;6:223. doi: 10.3389/fneur.2015.00223. eCollection 2015. Review.
PMID:26579067
Turner RC, Lucke-Wold BP, Logsdon AF, Robson MJ, Dashnaw ML, Huang JH,
Smith KE, Huber JD, Rosen CL, Petraglia AL. The Quest to Model Chronic
Traumatic Encephalopathy: A Multiple Model and Injury Paradigm Experience.
Front Neurol. 2015 Oct 20;6:222. doi: 10.3389/fneur.2015.00222. eCollection 2015.
PMID:26539159
Lucke-Wold BP, Naser ZJ, Logsdon AF, Turner RC, Smith KE, Robson MJ, Bailes
JE, Lee JM, Rosen CL, Huber JD. Amelioration of nicotinamide adenine
dinucleotide phosphate-oxidase mediated stress reduces cell death after blastinduced
traumatic brain injury. Transl Res. 2015 Dec;166(6):509-528.e1. doi:
10.1016/j.trsl.2015.08.005. Epub 2015 Sep 8. PMID:26414010
Lucke-Wold BP, Nguyen L, Turner RC, Logsdon AF, Chen YW, Smith KE, Huber
JD, Matsumoto R, Rosen CL, Tucker ES, Richter E. Traumatic brain injury and
epilepsy: Underlying mechanisms leading to seizure. Seizure. 2015 Dec;33:13-23.
doi: 10.1016/j.seizure.2015.10.002. Epub 2015 Oct 29. Review. PMID:26519659
Daffner SD, Sedney CL, Rosen CL. Migratory intradural disk herniation and a
strategy for intraoperative localization. Global Spine J. 2015 Feb;5(1):55-8. doi:
10.1055/s-0034-1381728. Epub 2014 Jul 24. PMID:25648315
Lucke-Wold, B.P., Turner, R.C., Logsdon, A.F., Nguyen, L., Bailes, J.E., Lee, J.M.,
Robson, M.J., Omalu, B.I., Smith, K.E., Huber, J.D., Rosen, C.L. (2015)
Endoplasmic Reticulum Stress Implicated in Chronic Traumatic Encephalopathy.
Journal of Neurosurgery. 18:1-16
Logsdon AF, Lucke-Wold BP, Nguyen L, Matsumoto RR, Turner RC, Rosen CL,
Huber JD. Salubrinal reduces oxidative stress, neuroinflammation and
impulsive-like behavior in a rodent model of traumatic brain injury.Brain Res.
2016 Jul 15;1643:140-51. doi: 10.1016/j.brainres.2016.04.063. Epub 2016 Apr 27.
PMID:27131989
Lucke-Wold BP, Logsdon AF, Manoranjan B, Turner RC, McConnell E, Vates GE,
Huber JD, Rosen CL, Simard JM. Aneurysmal Subarachnoid Hemorrhage and
Neuroinflammation: A Comprehensive Review.Int J Mol Sci. 2016 Apr 2;17(4).
pii: E497. doi: 10.3390/ijms17040497. Review. PMID:27049383
Lucke-Wold BP, Turner RC, Logsdon AF, Nguyen L, Bailes JE, Lee JM, Robson
MJ, Omalu BI, Huber JD, Rosen CL. Endoplasmic reticulum stress implicated in
chronic traumatic encephalopathy. J Neurosurgery. Accepted March 2015.
Lucke-Wold, B.P., Phillips, M., Turner, R.C., Logsdon, A.F., Smith, K.E., Huber,
J.D., Rosen, C.L., Regele, J. (2015) Elucidating the Role of Compression Waves
and Impact Duration for Generating mild Traumatic Brain Injury in Rats. Brain
Injury. Accepted.
Wu J, Pan C, Wimer B, Rosen CL. Finite element simulations of the head-brain
responses to the top impacts of a construction helmet: effects of the neck and
body mass. 12/2016., J Eng in Med,
http://journals.sagepub.com/doi/full/10.1177/0954411916678017.
Lucke-Wold BP, Logsdon AF, Nguyen L, Eltanahay A, Turner RC, Bonasso P,
Knotts C, Moeck A, Maroon JC, Bailes JE, Rosen CL. Supplements, Nutrition,
and Alternative Therapies for the Treatment of Traumatic Brain Injury. Accepted
9/2016, Nutritional Neuroscience (2016).
Turner, R.C., DiPasquale, K., Logsdon, A.F., Tan, Z., Naser, Z.J., Huber, J.D.,
Rosen, C.L., Lucke-Wold, B.P. (2016) The Role for Infarct Volume as a Surrogate
Measure of Functional Outcome Following Ischemic Stroke. Journal of Systems
and Integrative Neuroscience. 2(5):210-216.
Lucke-Wold, B.P., Turner, R.C., Urhie, O., Logsdon, A.F., Rosen, C.L., Qaiser, R.
(2016) Blast Scaling Parameters: Transitioning from Lung to Skull Base Metrics.
Journal of Surgery and Emergency Medicine. 1(1):3
Turner, R., Naser, Z., Lucke-Wold, B., Logsdon, A., Vangilder, R., Matsumoto, R.,
Huber, J., Rosen, CL (2016) LPS Preconditioning is Neuroprotective in a Diffuse
Axonal Injury Model and Associated with Glial Cell Modulation. Journal of
Neuroinflammation and Neuroimmunology. 4:6-15
Lucke-Wold, B.P., Logsdon, A.F., Turner, R.C., Huber, J.D., Rosen, C.L. (2016)
Endoplasmic Reticulum Stress Modulation as a Target for Ameliorating Effects of
Blast Induced Traumatic Brain Injury. Journal of Neurotrauma. Epub Ahead of
Print
Wu, J.Z., Pan, C.S., Wimer, B.M., Rosen, C.L. (2017) An improved finite element
modeling of the cerebrospinal fluid layer in the head impact analysis. Bio-Med
Mat and Eng 28:187-199.
Logsdon, A., Lucke-Wold, B.P., Turner, R., Li, X., Adkins, C., Mohammad, A.,
Huber, J., Rosen, C. Lockman, P. (2017) A Mouse Model of Focal Vascular Injury
induced Astrocyte Reactivity, Tau Oligomers, and Aberrant Behavior. Archives
of Neuroscience. Accepted
Gao, F., Lucke-Wold, B.P., Li, X., Logsdon, A.F., Xu, L.C., Xu, S., LaPenna, K.,
Talukder, M.A.H., Siedlecki, C., Huber, J.D., Rosen, C.L., He, P. (2017) Reduction
of endothelial nitric oxide increases the adhesiveness of constitutive endothelial
membrane ICAM-1 through Src-mediated phosphorylation. Reduction of
endothelial nitric oxide increases the adhesiveness of constitutive endothelial
membrane ICAM-1 through Src-mediated phosphorylation. Front Physio, 8:1124
Sizemore G, Lucke-Wold B, Rosen CL, Simpkins J, Bhatia S, and Sun D.
Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of
Hyperpolarized, Depolarized, and Flow-through Ion Channels Utilized as
Tricoordinate Biomarkers of Electrophysiologic Dysfunction. OBM- Neurobio
submitted 1/2018.
Logsdon AF*, Tan C*, Hernandez A*, Singh T, Turner RC, Lucke-Wold BP,
Huber JD, Alkon DL, Plattner F, Bibb JA, Rosen CL. Mild Blast Exposure
Induces Axonal Injury, Neuropsychological Deficits, and Excitotoxicity. J
Neurosci. In revision. *Denotes Equal Contribution of Authors
Tan ZJ, Lucke-Wold BP, Logsdon AF, Turner RC, Tan C, Li X, Hongpaison J,
Alkon DL, Huber JD, Rosen CL. Bryostatin attenuates blood-brain barrier
disruption and hemorrhagic transformation in acute ischemic stroke. In revision.
Barr TL, Huber JD, Turner RC, VanGilder RL, Ding J, Rosen CL, Matarin M,
Singleton A, Warach S. A-kinase anchor protein 7 (AKAP7) as a Mediator of
Blood Brain Barrier Disruption following Ischemic Stroke. In revision.

Book Chapters:

1. Rosen CL. Neuronal Expression of Glycosylphosphatidylinositol (GPI) – Anchored
Proteins: Heterogeneity of Expression and Their Potential Role in Neuron-Glial
Interactions. Thesis Advisor: James L. Salzer MD, PhD. [Ph.D. dissertation].
New York, NY: New York University; 1993.
2. Salzer JL, Rosen CL, Struyk AF. GPI-anchored proteins in neural cell adhesion.
In: Colman DR, ed. Cell Adhesion. Vol 16. Greenwich,CT: Jai Press; 1996:193.
3. Rosen CL, Keating RF. Supratentorial ependymoma. In: Keating RF, Goodrich J,
Packer R. Tumors of the Pediatric Central Nervous System. New York, NY: Thieme;
2001:239.
4. Wagner A, Pirici,D, Mogoanta L, Carmichael TS, DiNapoli V, Rosen CL,
Regeneration of tissue and function after cerebral ischemia in the aged rats: New
therapeutic strategies. In: Recent Advances and New Strategies in Stroke
Research Editor: Franciska Erdö, 2008, ISBN: 978-81-7895-385-4.
5. Popa-Wagner A, Pirici D, Zagrean AM, Petcu EB, Mogoanta L, Zagrean L, Rosen
CL, Leon R, HuberJ. Cerebral Circulation: Anatomy, Distribution and
Physiopathology. In: Pathophysiology of the vascular wall and its relevance for
cerebrovascular disorders in aged rodents” Ed Bernhardt LV, Nova Science
Publishers, Advances in Medicine and Biology 2009.
6. Turner RC, Elliott A, Huber JD, Rosen CL. A clinically relevant thromboembolic
stroke model in the aged rat. In TRP Channels in Drug Discovery: Methods in
Pharmacology and Toxicology, Springer/Humana Press (in press 2012).
7. Turner RC. Lucke-Wold B, Miller DB, O’Callaghan JP, Rosen CL HuberJD.
Neuropoetic cytokines and neural injury: alterations in JAK2/STAT3 signalling
associated with aging. In: Neurological Disorders: New Research, Nova Science
Publishers, 2012.
8. Turner RC, Lucke-Wold B, Rosen CL, Huber JD. Modulation of Protein Kinase C
Isoforms: A Potential Therapeutic for Neurologic Injury? In: Ischemic Stroke:
Symptoms, Prevention and Recovery, 2012.
9. Lucke-Wold, B.P., Logsdon, A.F., Turner, R.C., Rosen, CL (2014) Aging, the
Metabolic Syndrome, and Ischemic Stroke: Redefining the Approach for
Studying the Blood Brain Barrier in a Complex Neurological Disease. Advances
in Pharmacology.
10. 6.Logsdon, A.F., Lucke-Wold, B.P., Rosen, C.L., and Huber, J.D. (2016) Aging
and Cerebrovascular Dysfunction. Primer on Cerebrovascular Diseases.
Academic Press. 162-167
11. Lucke-Wold BP, Logsdon AF, Turner RC, Rosen CL, Huber JD. Aging and comorbidity
effects on the BBB. Advances in Pharmacology: The Pharmacology of
the Blood Brain Barrier. Edited by Thomas P. Davis.

Abstracts/Presentations (Selected):

1. Rosen CL, Wood PM, Bunge RP. Tissue culture studies indicate that myelination
by oligodendrocytes obtained from adult tissue is suppressed by astrocytes. J.
Neurosci. 1987; 13(2):1041(291.3).
2. Rosenbluth J, Hasegawa M, Shirasaki N, Rosen CL, Liu Z. Myelin formation in
myelin-deficient rat spinal cord after transplantation of normal fetal spinal cord
cultures. J. Neurosci. 1990; 15(1):10(8.5).
3. Rosen CL, Lisanti MP, Salzer JL. Expression of unique sets of
glycosylphosphatidylinositol (GPI)-anchored proteins by sensory, sympathetic,
and cerebellar neurons in vitro. J. Cell Biol. 1991; 115: 217(1261).
4. Rosen CL, Lisanti MP, Salzer J L. Differential expression of GPI-anchored proteins on
neurons in vitro. Gordon Conference on Myelin. 1992.
5. Struyk A, Rosen CL, Salzer JL. Characterization of the opiate binding-cell
adhesion molecule: an abundant GPI-anchored protein in the rat CNS. Mol. Bio.
Cell 3. 1992; 358a:2078.
6. Salzer J, Lisanti M, Rosen CL. Differential expression of GPI anchored proteins by
nerve fibers that differ in their ensheathment fates. Forum in Developmental Biology.
1992.
7. Rosen CL, Sekhar LN, Duong D. Intra-aortic balloon counterpulsation for refractory
symptomatic vasospasm. Abstract at the Congress of Neurological Surgery Annual
Meeting, 1997. New Orleans, LA.
8. Levine ZT, Buchanan RI, Sekhar LN, Rosen CL, Wright DW, Broemling L. A
proposed grading system to predict full resection in cranial base meningiomas. Abstract
at the American Association of Neurological Surgery Annual Meeting, 1998.
Philadelphia, PA.
9. Rosen CL, Ammerman J, Sekhar LN, Levine ZT, Bank WO. Outcome analysis of
preoperative embolization in cranial base surgery. Abstract at the Neurosurgical
Society of the Virginias, 2000. Sulpher Springs, VA.
10. Welch BG, Cruz LR, Rosen CL, Cooney FD, Kumar D. Chordoid glioma: a new
patient group in a new pathological entity. Abstract at the Washington Hospital
Center Research Forum, 2001. Washington DC.
11. Rosen CL, Ammerman J, Sekhar LN, Bank WO. Outcome analysis of preoperative
embolization in cranial base surgery. Abstract at the Congress of Neurological
Surgery Annual Meeting, 2001. San Diego, CA.
12. Wilkinson CC, Miele VJ, Nestor S, Rosen CL, Bailes JE. Phenytoin and Magnesium
Sulfate as Neuroprotective Agents in Acute Spinal Cord Injury. Abstract at the
American Association of Neurologic Surgeons Annual Meeting, 2002. Chicago,
IL.
13. Carr AM, Orphanos J, Rosen CL. Cervicospinal and basilar cranial fractures
resulting from motorcycle and all-terrain vehicle collisions in West Virginia: are they
helmet related? Abstract at the Congress of Neurological Surgery Annual Meeting,
2002. Philadelphia, PA.
14. Miele VJ, Rosen CL, Collins JJ, Bailes JE. Endoscopic third ventriculostomy for
hypertension secondary to obstructive hydrocephalus. Congress of Neurological
Surgeons Annual Meeting, 2003. Denver, CO.
15. Miele VJ, Rosen CL, Carpenter JP, Rai AT, Bailes JE. Vertebral artery to middle
cerebral artery bypass with coil embolization of giant internal carotid artery aneurysm.
Congress of Neurological Surgeons Annual Meeting, 2004. San Francisco, CA.
16. Rosen CL, DiNapoli VA, Nagamine T, Crocco T. The role of aging in the
pathophysiology of stroke. International Stroke Conference, 2005. New Orleans, LA.
17. Karlsson B, Rosen CL, Soderman M. Gamma knife surgery for cranial nerve
schwannomas. European Skull Base Meeting, 2005. Fulda, Germany.
18. Karlsson B, Rosen CL, Lax I, Yamamoto M, Söderman M, Jokura H, Bailes JE.
Calculation of isoeffective doses in single and multiple fraction radiation treatment for
brain AVMs by developing prediction outcome models. American Association of
Neurological Surgeons Annual Meeting, 2006. San Francisco, CA
19. Houser KA, Li X, Rosen CL, Huber JD: Role of NADPH oxidase on early bloodbrain
barrier disruption in the aged rat following ischemic stroke. Society of
Neuroscience, San Diego, CA. November 2007
20. Houser KA, Huber JD, DiNapoli VA, Rosen CL: Early disruption of BBB in aged
rats may contribute to exacerbated neuronal damage and prolonged functional
recovery following stroke. Van Liere Convocation, Morgantown, WV April 2007
21. Kelly KA, Li X, Rosen CL, Huber JD: Role of NADPH oxidase on early bloodbrain
barrier disruption in the aged rat following ischemic stroke. Van Liere
Convocation, Morgantown, WV April 2008
22. Kelly KA, Li X, Tan Z, Rosen CL, Huber JD: Role of NADPH oxidase on early
BBB disruption in the aged rat following ischemic stroke. GRC: Barrier of the
CNS, Tilton, NH June 2008
23. Sivak-Callcott JA, Rosen CL, Rassekh CH, Vandersloot P. Multidisciplinary
transbasal, orbital bar approach for midline skull base tumors involving the
orbit: ophthalmic considerations and outcomes. Second International Orbital
Society Symposium, Sept 26-27, 2008. New York, NY.
24. Sivak-Callcott JA, Rosen CL . Transcranial orbital decompression. American Society
of Ophthalmic Plastic Surgeons Annual Meeting, November 2008.
25. Harshbarger T, Rosen CL, Sedney CL, Sivak-Calcott J. Pre-operative Cranial
Modeling and Implant Design: An Innovative Approach to Craniofacial Fibrous
Dysplasia Reconstruction. Congress of Neurological Surgeons National Meeting
2006.
26. Kelly K, Li X, Tan Z, VanGilder R, Rosen CL, Huber JD: The effects of apocynin
on aged rats following MCAO and tPA reperfusion. Van Liere Convocation,
Morgantown, WV April 2009.
27. Shultz R, Ergas H, Vidor I, Rosen CL, Sivak-Callcott J: Polyetheretherketone
(PEEK) Implant for Orbital Reconstruction. ASOPRS 40TH Anniversary Fall
Scientific Symposium, San Francisco, CA Oct. 2009.
28. Torres-Trejo A, Haut M, Julien TD, Rosen CL, Boling WW, Altaha R, Fallon K,
Gyure K, Marano G: Retrospective study to identify if 99m Technetium-MIBI
SPECT has the same correlation as F-18-flouro-deoxy-D-glucose PET with the
final histological diagnosis according to the world health organization (WHO)
criteria in patients with brain tumors. Joint Meeting of the Society for NeuroOncology
and the AANS/CNS Section on Tumors, 2009.
29. Bulsara KR, Hoh BL, Rosen CL, Tanikawa R, Carpenter JS: Predicting the need
for coil extraction during microsurgery: the clip-coil ratio. Congress of
Neurological Surgery, New Orleans LA 2009.
30. Noro S, Sakai J, Rosen CL, Bailes JE, Fukushima T: Occipital transfalcian
transtentorial approach for resection of tumors in the posterior midline.
Congress of Neurological Surgery, New Orleans LA 2009.
31. Sakai J, Fukushima T, Noro S, Rosen CL, Bailes JE,: Interhemispheric precallosal
trans-septal approach (IPTSA) for the removal of craniopharyngiomas and other
third ventricular tumors. Congress of Neurological Surgery, New Orleans LA
2009.
32. Leon RL, Li X, Tan Z, Rosen CL, Huber JD. Estrogen Treatment Worsens Stroke
Outcome in Aged Female Rats. West Virginia University E.J. Van Liere Memorial
Convocation, April, 2010.
33. Mnatsakanova D, Leon RL, Li X, Rosen CL, Huber JD. Behavioral
Characterization of Middle Cerebral Artery Occlusion in Young Adult and Aged
Rats. West Virginia University E.J. Van Liere Research Day, April, 2010.
34. Leon R, Saunders J, Harris M, Williams HJ, Huber J, Rosen CL, Sivak-Callcott JA
Development of an Animal Model for the Study of Keratoconjunctivitis Sicca..
West Virginia University Van Liere Research Day, April, 2010.
35. Rosen, CL. How do I open the “expletive deleted” CD. AANS, May 2010.
36. Castro C, Meyer D, Tan Z, Kansy W, Tozzi A, DiFilippo M, DiNapoli V, Benkovic
S, Miller DB, Calabresi P, Rosen CL, Bibb JA. Aberrant Cdk5 causes ischemic
injury in stroke. Society for Neuroscience, San Diego CA 2010.
37. Leon RL, Li X, Tan Z, Rosen CL, Huber JD. Estrogen worsens outcome from
middle cerebral artery occlusion in aged rats. West Virginia University School of
Pharmacy Research Day, Morgantown WV, 2010.
38. R.C. Turner, K.A. Kelly, J.D. Huber, C.L. Rosen. “Role of aging and oxidative
stress in stroke outcome – interaction of the JAK/STAT signaling pathway and
NADPH oxidase.” Neurosurgical Society of the Virginias Annual Meeting,
White Sulphur Springs, WV, January 2011.
39. Sedney CL, Bafakih FF, Rosen CL, Gyure KA. Xanthogranulomatous
hypophysitis occurring in association with pituitary adenoma: A report of two
cases. American Association of Neuropathologists, Seattle WA 2011.
40. Saunders JA, León RL, Harris M, Williams HJ, Rosen CL, Huber JD, Sivak JA.
Determining effect of menopause on tear breakup time and lacrimal gland
function in rats. Association for Research in Vision and Ophthalmology, Ft.
Lauderdale Fl, 2011.
41. Saunders JA, León RL, Harris M, Williams HJ, Rosen CL, Huber JD, Sivak JA.
Development of An Animal Model For The Study of Keratoconjunctivitis Sicca.
Association for Research in Vision and Ophthalmology, Ft. Lauderdale Fl, 2011.
42. R.C. Turner, Z.J. Naser, J.E. Bailes, D.W. Smith, J.A. Fisher, C.L. Rosen. “Effect of
Slosh Mitigation on Histologic Markers of Traumatic Brain Injury.”
Neurosurgical Society of the Virginias Annual Meeting, White Sulphur Springs,
WV, January 2012
43. Turner RC, Naser ZJ, Bailes JE, Smith DW, Fisher JA, Rosen CL. Effect of
Internal Jugular Vein Compression on Traumatic Brain Injury – A Histologic
Approach to Studying Slosh Mitigation. American Association of Neurological
Surgeons. Miami, Florida, April ,2012.
44. VanGilder RL, Turner R*, Rellick SL, Barr TL, Rosen CL, Huber JD. The Effects of
Lipopolysaccarhide Preconditioning on a Diffuse Axonal Injury TBI. National
Captial Area TBI Research Symposium, Bethesda, MD April 2012.
45. Logsdon, A.F., Turner, R.C., Tan, Z., DiPasquale, K., Lucke-Wold, B.P., Rosen,
C.L., Huber, J.D. (2012) Alterations to the JAK2/STAT3 signaling pathway may
affect ER stress levels in the aged rat stroke model. WVU Center for
Neuroscience Annual Retreat.
46. Tan, Z., Li, X., Turner, R.C., Logsdon, A., Lucke-Wold, B.P., DiPasquale, K.,
Chen, R., Rosen, C.L., Huber, J.D. (2012) Combination treatment of r-tPA and
APT 102 reduces cerebral infarct volume, improves neurological deficit score and
prevents hemorrhagic transformation in embolic stroke in aged female rats.
WVU Center for Neuroscience Annual Retreat.
47. Lucke-Wold, B.P., Turner, R.C., DiPasquale, K., Rosen, C.L., Huber, J.D. (2012)
Pressure Wave: a Membrane-Rupture Induced Model of Traumatic Brain Injury.
WVU Center for Neuroscience Annual Retreat.
48. A. Logsdon, R.C. Turner, Z. Tan, K. DiPasquale, B. Lucke-Wold, C.L. Rosen, J.D.
Huber. Alterations to the JAK2/STAT3 signaling pathway may affect ER stress
levels in the aged rat stroke model. WVU Center for Neuroscience Annual
Retreat, Snowshoe Resort, Snowshoe, WV, July 2012.
49. B.P. Lucke-Wold, R.C. Turner, K. DiPasquale, J.D. Huber, C.L. Rosen. Explosive
Exposure: A Blast-Induced Model of Traumatic Brain Injury. WVU Center for
Neuroscience Annual Retreat, Snowshoe Resort, Snowshoe, WV, July 2012.
50. K. DiPasquale, R.C. Turner, A. Logsdon, Z. Tan, C.L. Rosen, J.D. Huber.
Increasing Clinical Relevance of Preclinical Ischemic Stroke Models: Infarct
Volume and Function Correlation. WVU Center for Neuroscience Annual
Retreat, Snowshoe Resort, Snowshoe, WV, July 2012.
51. R.C. Turner*, R.L. VanGilder*, S.L. Rellick, T.L. Barr, C.L. Rosen, J.D. Huber.
Modulation of Innate-Adaptive Immune System Cross-Talk for Neuroprotection:
The Role of Lipopolysaccharide in Diffuse Axonal Injury. National Neurotrauma
Symposium, Phoenix, AZ, July 2012. (* denotes co-authorship)
52. R.L. VanGilder*, R.C. Turner*, S.L. Rellick, T.L. Barr, C.L. Rosen, J.D. Huber. The
Effects of Lipopolysaccharide Preconditioning on a Diffuse Axonal Injury TBI.
National Capital Area TBI Research Symposium. National Institutes of Health.
May 2012. (* denotes co-authorship)
53. N. St. John, R.C. Turner, C.L. Rosen, R.T.T. Gettens. Design of a Blast Wave
Characterization Model. American Society for Engineering Education – North
East Section, Lowell, MA, April 2012.
54. R.C. Turner, Z.J. Naser, J.E. Bailes, D.W. Smith, J.A. Fisher, C.L. Rosen. Effect of
Internal Jugular Vein Compression on Traumatic Brain Injury – A Histologic
Approach to Studying Slosh Mitigation. American Association of Neurological
Surgeons Annual Meeting, Miami, FL, April 2012.
55. R.C. Turner, Z.J. Naser, J.E. Bailes, D.W. Smith, J.A. Fisher, C.L. Rosen, J.D.
Huber. Effect of Slosh Mitigation on Histologic Markers of Traumatic Brain
Injury. West Virginia University Van Liere Research Day, Morgantown, WV,
March 2012.
56. A.S. Elliott, R.C. Turner, J.P. O’Callaghan, C.L. Rosen, J.D. Huber, D.B. Miller.
Using RNA-Seq to evaluate the aged female Sprague-Dawley rat cortex
transcriptome after repeated bouts of sleep deprivation induced by the gentlehandling
method. Society for Neuroscience, New Orleans, LA, October 2012.
57. A.F. Logsdon, R.C. Turner, M.J. Robson, Z.J. Naser, K. DiPasquale, C.L. Rosen,
J.D. Huber. Characterization of the PERK-mediated ER stress pathway following
traumatic brain injury in male rats: A role in neural injury and degeneration.
West Virginia University Van Liere Research Day, Morgantown, WV, March
2013.
58. R.L. VanGilder, S.L. Rellick, J.D. Huber, C.L. Rosen, R.C. Turner. An association
between TLR and JAK signaling following cerebral ischemia: A Translational
Approach. International Stroke Conference, Honolulu, HI, February 2013.
59. A.S. Elliott, R.C. Turner, J.P. O’Callaghan, C.L. Rosen, J.D. Huber, D.B. Miller.
Lucke-Wold, B.P. Logsdon, A.F., Turner, R.C., Huber, J.D., Rosen, C.L. (2014)
Linking Acute Neurotrauma to Chronic Traumatic Encephalopathy: the Role of
the ER Stress Response. Van Liere.
60. B.P. Lucke-Wold, A.F. Logsdon, R.C. Turner, J.D. Huber, C.L. Rosen. Linking
Acute Neurotrauma to Chronic Traumatic Encephalopathy: the Role of the ER
Stress Response. West Virginia University Van Liere Research Day,
Morgantown, WV, February 2014.
61. B.P. Lucke-Wold, A.F. Logsdon, R.C. Turner, J.D. Huber, C.L. Rosen. PERKmediated
ER Stress: Linking Acute Blast-induced Neurotrauma with Taudependent
Neurodegeneration. American College of Physicians National
Meeting, Orlando, FL, April 2014.
62. B.P. Lucke-Wold, A.F. Logsdon, R.C. Turner, J.E. Bailes, J. Lee, J.D. Huber, C.L.
Rosen. PERK-mediated ER Stress: Linking Acute Blast-induced Traumatic Brain
Injury with Chronic Traumatic Encephalopathy. American Physician Scientist
Association, Chicago, IL, June 2014.
63. B.P. Lucke-Wold, A.F. Logsdon, R.C. Turner, J.E. Bailes, J. Lee, J.D. Huber, C.L.
Rosen. Connecting Acute Neurotrauma to Chronic Traumatic Encephalopathy:
the Role of the ER Stress Response. National Neurotrauma Society, San
Francisco, CA, July 2014.
64. Lucke-Wold, B.P., Naser, Z., Logsdon, A.F., Turner, R.C., Bailes, J.E., Lee, J.,
Huber, J.D., Rosen, C.L. (2015) Reducing Oxidative Stress Following Acute
Neurotrauma Improves Behavior. ASPET Experimental Biology.
65. Lucke-Wold, B.P., Logsdon A.F., Turner, R.C., Naser, Z., Bailes, J.E., Lee, J. Rosen
C.L. (2015) Elucidating the Underpinnings of Neurotrauma Related
Neurodegeneration ACTS: AFMR Translational Science.
66. Lucke-Wold, B.P., Logsdon A.F., Turner, R.C., Naser, Z., Bailes, J.E., Lee, J.,
Rosen C.L. (2015) Amelioration of NADPH-mediated Stress Reduces Cell Death
following Blast Traumatic Brain Injury. Central Society of Clinical and
Translational Research
67. Lucke-Wold, B.P., Logsdon A.F., Turner, R.C., Naser, Z., Bailes, J.E., Lee, J.,
Rosen C.L. (2015). Lipoic Acid: the Anti-Oxidant for Neurotrauma. American
Society of Clinical Investigation.
68. Lucke-Wold, B.P., Logsdon A.F., Turner, R.C., Naser, Z., Bailes, J.E., Lee, J.,
Rosen C.L. (2015). Finding Treatments for Athletes and Soldiers Experiencing
Brain Injury. American College of Physicians.
69. Lucke-Wold, B.P., Xu, S., Logsdon, A.F., Rosen, C.L., He, P. (2015) Targeting
Endothelial Cell Transcellular Diapedesis: Src Dependent Activation of ICAM-1.
American Association of Pharmaceutical Sciences Research Day. West Virginia
University.
70. Lucke-Wold, B.P., Turner, R., Dashnaw, M., Lee, J., Rosen, C., Petraglia, A. (2015)
Modeling Chronic Neurodegeneration Following Neurotrauma: A Multi-Model
Experience. National Neurotrauma Meeting.
71. Lucke-Wold, B.P., Logsdon, A.F., Mohammad, A., Adkins, C., Ren, X., Lockman,
P., Simpkins, J., Rosen, C. (2015) Stroke and Alzheimer’s Disease: Shared
Vascular Mechanisms. WV Rural Health Meeting.
72. Lucke-Wold, B.P. Logsdon, A., Turner, R.C., Lockman, P., Simpkins, J., Rosen, C.
(2015) Novel Approach for Concussion Treatment: Protein Kinase C and the
Blood Brain Barrier. American Association of Pharmaceutical Sciences Meeting.
73. Lucke-Wold, B.P. Logsdon, A.F., Mohammad, A., Adkins, C., Ren, X., Lockman,
P., Simpkins, J., Rosen, C. (2015) Understanding the Vascular Inter-relationship
Between Stroke and Alzheimer’s Disease. Future Tox 2015 Washington, D.C.
74. Lucke-Wold, B.P., Logsdon, A., Mohammad, A., Adkins, C., Ren, X., Simpkins, J.,
Lockman, P., Rosen, C. (2016) The Vascular Inter-relationship between Stroke
and Alzheimer’s disease. International Stroke Conference.
75. Lucke-Wold, B.P., Logsdon, A., Turner, R., Simpkins, J., Lockman, P., Huber, J.,
Rosen, C. (2016) Trauma-Induced Blood Brain Barrier Disruption: an Innovative
Approach for Treating Concussion. American Society of Pharmacology and
Experimental Therapeutics.
76. Lucke-Wold, B.P., Logsdon, A., Turner, R., Simpkins, J., Lockman, P., Huber, J.,
Rosen, C. (2016) A Novel Treatment for Concussion: Targeting Blood Brain
Barrier Disruption and Secondary Injury Cascades. American Academy of
Neurology.
77. Lucke-Wold, B.P., Logsdon, A., Turner, R.C., Simpkins, J., Lockman, P., Huber, J.,
Rosen, C. (2016) Blood Brain Barrier Disruption and Neurotrauma: Elucidating
the Role of Neuroinflammation and Gliosis. American Association of
Neurological Surgeons.
78. Lucke-Wold, B.P., Turner, R.C., Logsdon, A.F., Nguyen, L., Bailes, J.E., Lee, J.M.,
Robson, M.J., Omalu, B.I., Huber, J.D., Rosen, C.L. (2016) Endoplasmic
Reticulum Stress Implicated in Chronic Traumatic Encephalopathy. National
IdEA Symposium of Biomedical Research Excellence.
79. Lucke-Wold, B.P., Logsdon, A.F., Turner, R.C., Mohammad, A., Adkins, C.,
Huber, J., Rosen, C.L., Lockman, P. (2016) A Novel Treatment for Concussion:
Targeting Protein Kinase C Activity and Blood Brain Barrier Disruption. Gordon
Research Seminar Barriers of the CNS.
80. Lucke-Wold, B.P., Logsdon, A.F., Turner, R.C., Bailes, J., Lee, J., Robson, M.,
Huber, J., Rosen, C.L. (2016) Endoplasmic Reticulum Stress Implicated in the
Progression of Chronic Traumatic Encephalopathy. NISBRE.
81. Lucke-Wold, B.P., Logsdon, A.F., Turner, R.C., Urhie, O., Lockman, P., Rosen,
C.L., Simpkins, J. (2016) Bryostatin Regulates MicroRNA and Protects the Blood
Brain Barrier. WVU Neuroscience Retreat.
82. Lucke-Wold, B.P., Logsdon, A.F., Turner, R.C., Simpkins, J.W., Rosen, C.L. (2017)
Using Bryostatin to prevent microRNA activation following neurotrauma: a
novel approach to targeting the blood brain barrier. VanLiere Research Day.
WVU
83. Lucke-Wold, B.P., Logsdon, A.F., Turner, R.C., Lockman, P., Rosen, C.L., Qaiser,
R. (2017) A Mouse Model of Focal Vascular Injury Induces Astrocyte Reactivity,
Tau Oligomers, and Aberrant Behaviour. National Neurotrauma Meeting.